Mature cardiac cells remain metabolically active but do not proliferate. this type of arrest is known as the G o phase.
The stages of a cell cycle is divided into four phases namely the G1 phase, S phase (synthesis), G2 phase (interphase) and M phase (mitosis or meiosis). But the cells that have stopped dividing are said to have entered a phase of quiescence called the G o phase.
G o phase refers to a non-dividing cellular phase outside the replicative cell cycle. The cells in this stage remain metabolically active but do not divide and increase in their number. G o phase irreversible in the differentiated cells of bone, cardiac muscle and nerve. The cardiomyocytes or the heart muscle cells simply increase in size as the heart goes larger.
Thus, the mature or differentiated cardiac cells remain metabolically active but do not divide and get arrested in the G o phase of cell division.
