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Pyruvate dehydrogenase is the entry point for the glycolytic product pyruvate into oxidative metabolism (the citric acid cycle and oxidative phosphorylation). Because it occupies such an important checkpoint in metabolism, it is tightly regulated. Determine whether the given conditions promote entry into oxidative metabolism or limit entry into oxidative metabolism. These abbreviations may be used: PDH PDH is pyruvate dehydrogenase; PDK PDK is pyruvate dehydrogenase kinase; PDP PDP is pyruvate dehydrogenase phosphatase. (A) Oxidative metabolism increases(B) Oxidative metabolism is limited

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Answer:

(A) Oxidative metabolism increases

There will be an increase in oxidative metabolism if the following conditions are present;

1. High O2 levels, active PDH

2. High O2 levels, PDK inhibitor present.

(B) Oxidative metabolism is limited

Oxidative metabolism will be limited if the following conditions are given;

1. low O2 levels, inactive PDH

2. high O2 levels, PDK active

3. Low O2 levels, PDK active

Note: PDK is pyruvate dehydrogenase kinase; PDP is pyruvate dehydrogenase phosphatase.

Explanation:

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