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affinity maturation-

because antibodies can potentially be generated against millions of unique epitopes, the size of an organisim's genome would need to increase exponentially in order to every possible antigen- binding side.


Description
In immunology, affinity maturation is the process by which TFH cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response. With repeated exposures to the same antigen, a host will produce antibodies of successively greater affinities.