What is the best definition of addiction?

Addiction is a chronic problem in which a person has altered his or her brain and can’t stop taking a substance.

Addiction is a social problem in which a person suffers negative effects in his or her life from taking a substance.

Addiction is a condition in which a person has an intense craving for a substance that is difficult to resist.

Addiction is when a person takes so much of a substance that serious effects occur requiring hospitalization