The most significant factor contributing to widespread edema brought on by decreased plasma protein production in chronic liver disease is hypoalbuminemia, which manifests in end-stage liver disease. It leads to the increase on capillary filtration/absorption .
The osmotic pressure in blood arteries is maintained in large part by plasma proteins, which are also crucial carriers of several chemicals, including hormones. Blood pressure is the main factor influencing Glomerular filtration rate (GFR), which is countered by Bowman's capsule fluid pressure and colloid osmotic pressure brought on by plasma proteins.
The plasma has a lower than usual colloid osmotic pressure because there are less plasma proteins present. GFR rises when there is less colloid osmotic pressure working against it.
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