A patient produced 1500 mL of urine in a 24-hour period. This patient had a urine creatinine concentration of 10 mmol/L and a plasma creatinine concentration of 100 mmol/L. Calculate the creatinine clearance in mL/min.

Question

02-03-2024
Chemistry

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A patient produced 1500 mL of urine in a 24-hour period. This patient had a urine creatinine concentration of 10 mmol/L and a plasma creatinine concentration of 100 mmol/L. Calculate the creatinine clearance in mL/min.

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icetornato icetornato · Answer 1 · 2024-03-02T08:04:06+01:00

To calculate creatinine clearance, you can use the following formula:

Creatinine Clearance

=

Urine Flow Rate

×

Urine Creatinine Concentration

Plasma Creatinine Concentration

Creatinine Clearance=

Plasma Creatinine Concentration

Urine Flow Rate×Urine Creatinine Concentration

First, we need to convert the urine flow rate from mL/day to mL/min:

Urine Flow Rate

=

1500

mL

24

hours

×

1

hour

60

min

=

1500

24

×

60

mL/min

=

1.0417

mL/min

Urine Flow Rate=

24 hours

1500 mL

×

60 min

1 hour

=

24×60

1500

mL/min=1.0417 mL/min

Now, we can calculate the creatinine clearance:

Creatinine Clearance

=

1.0417

mL/min

×

10

mmol/L

100

mmol/L

Creatinine Clearance=

100 mmol/L

1.0417 mL/min×10 mmol/L

Creatinine Clearance

=

1.0417

×

10

100

mL/min

Creatinine Clearance=

100

1.0417×10

mL/min

Creatinine Clearance

=

0.10417

mL/min

Creatinine Clearance=0.10417 mL/min

So, the creatinine clearance is approximately

0.10417

mL/min

0.10417 mL/min.