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__________ is a condition in which large number of liver lobules are destroyed and replaced by permanent, scar-like connective tissue.

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Hi the answer to your question is Cirrhosis. This is usually when a person is an excessive drinker.
Hope this helps.
Karollina
Cirrhosis is a condition in which large number of liver lobules are destroyed and replaced by permanent, scar-like connective tissue.

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