First,
let us define each word with their dictionary definitions:
Confuse
is making a person not certain or unable to understand onto something.
Meander
is a ‘winding path or course’ (e.g. a river or a road)
Harangue
is a speech which is forceful or angry
Distract
is causing someone ‘to stop thinking about or paying attention’ onto something
or someone
With
the words and their meaning, the word that is most likely to have a negative
flavor or connotation is letter C: Harangue.